Detection of Carboxylesterase 1 and Chlorpyrifos with ZIF-8 Metal–Organic Frameworks Using a Red Emission BODIPY-Based Probe
- 11 February 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Applied Materials & Interfaces
- Vol. 13 (7), 8718-8726
- https://doi.org/10.1021/acsami.0c19811
Abstract
In this work, a red emission fluorescent probe [email protected] imidazolate framework-8 (ZIF-8) was fabricated based on metal–organic frameworks (MOFs) for detecting carboxylesterase 1 (CES1). The small molecule probe CBZ-BOD was first synthesized and then used to prepare the functionalized MOF material. ZIF-8 was chosen as an encapsulation shell to improve the detection properties of CBZ-BOD. Using this unique porous materials, ultrasensitive quantification of CES1 and chlorpyrifos was successfully realized. The low detection limit and high fluorescence quantum yield were calculated as 1.15 ng/mL and 0.65 for [email protected], respectively. [email protected] has good biocompatibility and was successfully applied to monitor the activity of CES1 in living cells. A molecular docking study was used to explore the binding of CES1 and CBZ-BOD, finding that CES1 can bind with the probe before and after hydrolysis. This type of materialized probe can inspire the development of fluorescent tools for further exploration of many pathological processes.Keywords
Funding Information
- Natural Science Foundation of Jiangsu Province (BK20200728)
- National Natural Science Foundation of China (22007048, 22007049)
- Science and Technology Innovation Project for Overseas Students of Nanjing in 2020 (184080H201148)
- Jiangsu Specially-Appointed Professor Project to Xing Zhang
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China (20KJB150046)
- Jiangsu innovation and entrepreneurship doctoral program to Baoxing Shen
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