Derivation and validation of a clinical prediction rule for thrombolysis-associated major bleeding in patients with acute pulmonary embolism: the BACS score
- 23 July 2020
- journal article
- research article
- Published by European Respiratory Society (ERS) in European Respiratory Journal
- Vol. 56 (6), 2002336
- https://doi.org/10.1183/13993003.02336-2020
Abstract
Background Improved prediction of the risk of major bleeding in patients with acute pulmonary embolism (PE) receiving systemic thrombolysis is crucial to guide the choice of therapy. Methods The study included consecutive patients with acute PE who received systemic thrombolysis in the RIETE registry. We used multivariable logistic regression analysis to create a risk score to predict 30-day major bleeding episodes. We externally validated the risk score in patients from the COMMAND VTE registry. We also compared the newly created risk score against the Kuijer and RIETE scores. Results Multivariable logistic regression identified four predictors for major bleeding: recent major Bleeding (3 points), Age >75 years (1 point), active Cancer (1 point), and Syncope (1 point) (BACS). Among 1172 patients receiving thrombolytic therapy in RIETE, 446 (38%) were classified as having low-risk (none of the variables present, 0 points) of major bleeding according to the BACS score, and the overall 30-day major bleeding rate of this group was 2.9% (95% CI, 1.6–4.9%), compared with 44% (95% CI, 14–79%) in the high-risk group (>3 points). In the validation cohort, 51% (149/290) of patients were classified as having low-risk, and the overall 30-day major bleeding rate of this group was 1.3%. In RIETE, the 30-day major bleeding event rates in the Kuijer and RIETE low-risk stratum were 5.3% and 4.4%, respectively. Conclusions The BACS score is an easily applicable aid for prediction of the risk of major bleeding in the population of PE patients who receive systemic thrombolysis.Keywords
Funding Information
- Sanofi España
This publication has 34 references indexed in Scilit:
- Thrombolytic therapy and outcome of patients with an acute symptomatic pulmonary embolismJournal of Thrombosis and Haemostasis, 2012
- Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE RegistryThrombosis and Haemostasis, 2008
- Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimationStatistics in Medicine, 2004
- Recurrent venous thromboembolism and bleeding complications during anticoagulant treatment in patients with cancer and venous thrombosisBlood, 2002
- Should scoring rules be based on odds ratios or regression coefficients?Journal of Clinical Epidemiology, 2002
- Internal validation of predictive models: Efficiency of some procedures for logistic regression analysisJournal of Clinical Epidemiology, 2001
- Prognostic Modeling with Logistic Regression AnalysisMedical Decision Making, 2001
- Clinical prediction rulesJournal of Clinical Epidemiology, 1997
- Predictive value of statistical modelsStatistics in Medicine, 1990
- Best Subsets Logistic RegressionBiometrics, 1989