Weak-evidence Fusion Candidates Detected by a FusionPlex Assay Using the Ion Torrent System
- 23 February 2021
- journal article
- research article
- Published by Anticancer Research USA Inc. in In Vivo
- Vol. 35 (2), 993-998
- https://doi.org/10.21873/invivo.12342
Abstract
Background/Aim: The Archer FusionPlex platform is widely used for comprehensive fusion-gene detection in cancer tissues. This platform separately displays results for strong-evidence and weak-evidence fusion candidates (WEFCs). Distinctive fusion patterns are frequently found in the weak-evidence category and information about the patterns is clinically essential. Patients and Methods: We describe the type and frequency of WEFCs observed using the FusionPlex Sarcoma Panel (S Panel) and the FusionPlex ALK, RET, and ROS1 ver2 Panel (ARR Panel). Results: A total of 97 specimens were examined and 620 candidates were detected and categorized as WEFCs. A median of five WEFCs were detected per sample. In the S Panel group, there were 13 WEFCs with a frequency of more than 1%. In the ARR Panel group, a total of 16 WEFCs were detected with a frequency of more than 1%. Conclusion: Specific WEFCs were detected according to the panel selected.Keywords
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