The prognostic impact of the extent of ulceration in patients with clinical stage I– II melanoma: a multicentre study of the Italian Melanoma Intergroup ( IMI )
- 13 April 2020
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 184 (2), 281-288
- https://doi.org/10.1111/bjd.19120
Abstract
Background The presence of ulceration has been recognized as an adverse prognostic factor in primary cutaneous melanoma (PCM). Objective To investigate whether the extent of ulceration (EU) predicts relapse free survival (RFS) and overall survival (OS) in PCM. Methods 477 patients with ulcerated PCM were retrieved from databases of Italian Melanoma Intergroup. Univariate and multivariable Cox proportional hazard models were used to assess the independent prognostic impact of EU. Results A significant interaction emerged between Breslow thickness (BT) and EU considering both RFS (p4 mm BT. Conclusion This study demonstrated that EU has an independent prognostic impact in PCM and should be recorded as a required element in pathology reports.Funding Information
- Italian Melanoma Intergroup (IMI, grant 3/2015)
This publication has 28 references indexed in Scilit:
- Prognostic factors in invasive cutaneous malignant melanoma: a population-based study and reviewMelanoma Research, 2001
- Prognostic Factors Analysis of 17,600 Melanoma Patients: Validation of the American Joint Committee on Cancer Melanoma Staging SystemJournal of Clinical Oncology, 2001
- Prognosis of thick cutaneous melanomaJournal of the American College of Surgeons, 1999
- Malignant Melanoma Prognostic Factors 4: Ulceration WidthThe Journal of Dermatologic Surgery and Oncology, 1984
- A Comparison of Prognostic Factors and Surgical Results in 1,786 Patients with Localized (Stage I) Melanoma Treated in Alabama, USA, and New South Wales, AustraliaAnnals of Surgery, 1982
- Ulceration and prognosis in cutaneous malignant melanomaHistopathology, 1982
- Prognostic Factors for Patients with Clinical Stage I Melanoma of Intermediate Thickness (1.51–3.99 mm)* A Conceptual Model for Tumor Growth and MetastasisAnnals of Surgery, 1982
- The prognostic significance of ulceration of cutaneous melanomaCancer, 1980
- Cutaneous melanoma: Ulceration as a prognostic signCancer, 1953
- Malignant melanoma. A clinicopathological analysis of the criteria for diagnosis and prognosisCancer, 1953