Store-Independent Calcium Entry and Related Signaling Pathways in Breast Cancer

Abstract

Known as a key effector in breast cancer (BC) progression, calcium (Ca²⁺) is tightly regulated to maintain the desired concentration to fine-tune cell functions. Ca²⁺ channels are the main actors among Ca²⁺ transporters that control the intracellular Ca²⁺ concentration in cells. It is well known that the basal Ca²⁺ concentration is regulated by both store-dependent and independent Ca²⁺ channels in BC development and progression. However, most of the literature has reported the role of store-dependent Ca²⁺ entry, and only a few studies are focusing on store-independent Ca²⁺ entry (SICE). In this review, we aim to summarize all findings on SICE in the BC progression field.