The Current State of Research Regarding the Role of Non-Coding RNAs in Cutaneous Squamous Cell Carcinoma
Open Access
- 1 January 2020
- journal article
- research article
- Published by Taylor & Francis Ltd in OncoTargets and Therapy
- Vol. 13, 13151-13158
- https://doi.org/10.2147/OTT.S271346
Abstract
Skin cancers, including those of both both melanoma and non-melanoma sub-types, remain among the most common forms of human cancer. Non-melanoma skin cancers are typically further differentiated into the basal cell carcinoma and cutaneous squamous cell carcinoma (cSCC) categories. Current approaches to diagnosing and treating cSCC remain unsatisfactory, and the prognosis for patients with this disease is relatively poor. Recent advances in high-throughput sequencing have led to an increasingly robust understanding of the diversity of non-coding RNAs (ncRNAs) expressed in both physiological and pathological contexts. These ncRNAs include microRNAs, long ncRNAs, and circular RNAs, all of which have been found to play key functional roles and/or to have value as diagnostic biomarkers or therapeutic targets in a range of different disease contexts. The number of ncRNAs associated with cSCC continues to rise, and as such, there is clear value in comprehensively reviewing the functional roles of these molecules in this form of cancer in order to highlight future avenues for research and clinical development.This publication has 57 references indexed in Scilit:
- EGFRvIII Expression in Squamous Cell Carcinoma of the SkinJAMA Dermatology, 2013
- The diverse role of miR‐31 in regulating cancer associated phenotypesGenes, Chromosomes and Cancer, 2013
- A miR-34a-SIRT6 axis in the squamous cell differentiation networkThe EMBO Journal, 2013
- A novel onco-miR-365 induces cutaneous squamous cell carcinomaCarcinogenesis: Integrative Cancer Research, 2013
- Circular RNAs are abundant, conserved, and associated with ALU repeatsRNA, 2012
- Control of somatic tissue differentiation by the long non-coding RNA TINCRNature, 2012
- MicroRNA-125b Down-regulates Matrix Metallopeptidase 13 and Inhibits Cutaneous Squamous Cell Carcinoma Cell Proliferation, Migration, and InvasionOnline Journal of Public Health Informatics, 2012
- Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and TumorigenesisCancer Cell, 2011
- Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip: Implications for treatment modality selectionJournal of the American Academy of Dermatology, 1992
- Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures.Proceedings of the National Academy of Sciences of the United States of America, 1976