Effect of the time interval between oocyte retrieval and ICSI on embryo development and reproductive outcomes: a systematic review
Open Access
- 1 March 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Reproductive Biology and Endocrinology
- Vol. 19 (1), 1-12
- https://doi.org/10.1186/s12958-021-00717-0
Abstract
Intra-cytoplasmic sperm injection (ICSI) is used in assisted reproductive technology (ART) laboratories. However, there is no consensus regarding the precise time intervals within ICSI cycles [oocyte pick up (OPU), oocyte denudation (DN), and ICSI], and results are inconsistent and contradictory. Thus, we aim to evaluate whether there is a concordance regarding the time intervals used in different laboratories and a concrete time that gives better laboratory and reproductive results. A systematic review of the literature until July 25, 2020, was performed with the keywords “Oocyte Denudation/Denudation/Oocyte,” “Intra-cytoplasmic Sperm Injection/ICSI,” “Oocyte/Oocyte maturation/ cumulus,” and “Cumulus removal/ removal.” Articles and abstracts in English and involving human subjects referring to the effects of oocyte DN time on embryo development and clinical outcomes were included. Of the 294 evaluated articles, 24 (including 20 full articles and 4 abstracts) were included in this review. Eighteen studies analysed the effect of OPU-DN time on embryo development and clinical outcomes. Most of these studies concluded that OPU-DN time did not influence ICSI outcomes, but some suggested that oocytes should be incubated for a short time before DN to improve oocyte maturity and enhance ICSI outcomes. In addition to reports on positive or negligible effects, adverse effects were reported in 12 studies on DN-ICSI timing. Neither OPU-DN nor DN-ICSI time could improve live birth rate. Oocytes should be pre-incubated for a short duration (preferably < 4 h) before DN according to the ART laboratory schedule. More randomised controlled trials are warranted to clarify the effect of DN-ICSI timing on ICSI outcomes.Keywords
Funding Information
- Peking Union Medical College Hospital (ZC201904363)
This publication has 62 references indexed in Scilit:
- Roles of MAPK and Spindle Assembly Checkpoint in Spontaneous Activation and MIII Arrest of Rat OocytesPLOS ONE, 2012
- Optimal Timing for Oocyte Denudation and Intracytoplasmic Sperm InjectionObstetrics and Gynecology International, 2012
- Protein Profile Changes during Porcine Oocyte Aging and Effects of Caffeine on Protein Expression PatternsPLOS ONE, 2011
- In Vitro Ageing of Porcine Oocytes: Changes in Phosphorylation of the Mitogen‐Activated Protein Kinase (MAPK) and Parthenogenetic ActivabilityReproduction in Domestic Animals, 2010
- The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomesThe International Journal of Biochemistry & Cell Biology, 2010
- Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competenceCanadian Journal of Physiology and Pharmacology, 2010
- A 38 h interval between hCG priming and oocyte retrieval increases in vivo and in vitro oocyte maturation rate in programmed IVM cyclesHuman Reproduction, 2008
- Oocyte cytoplasmic maturation: A key mediator of oocyte and embryo developmental competence1Journal of Animal Science, 2007
- In vivo maturation of oocytes by extending the interval between human chorionic gonadotropin administration and oocyte retrievalFertility and Sterility, 2006
- Parthenogenesis of human oocytes as a function of vacuum pressureJournal of Assisted Reproduction and Genetics, 1989