Role of glutathione S-transferase P1 polymorphism in early transplant complications in patients undergoing allogeneic stem cell transplantation
- 1 January 2021
- journal article
- research article
- Published by Medknow in Journal of Cancer Research and Therapeutics
- Vol. 17 (2), 565-573
- https://doi.org/10.4103/jcrt.jcrt_61_20
Abstract
Introduction: Complications in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) cause serious morbidity and mortality. Predicting patients at risk in advance and changing the symptomatic care and/or preparation regimen according to this risk assessment have been emphasized recently. Several single-nucleotide polymorphisms have been studied, and some were found to be responsible for early complications. Glutathione S-transferase P1 (GSTP1) is an enzyme involved in the detoxification process that reduces oxidative stress by reducing the number of free oxygen radicals. Aim: This study aimed to investigate the relationship between GSTP1 polymorphism and early complications of allo-HSCT, iron parameters, overall survival (OS), and transplantation-related mortality (TRM). Materials and Methods: A total of 50 patients diagnosed with acute myeloid leukemia (n = 23) or acute lymphoblastic leukemia (n = 27) who underwent allo-HSCT between May 2008 and February 2011 at Gazi University Faculty of Medicine, Stem Cell Transplantation Unit, were included. Results: Of the 50 patients, 24 (48%) were women and 26 (52%) were men. The median age of the patients was 26 (16–74) years. GSTP1 polymorphism was detected in 23 (46%) patients, and 27 (54%) had no polymorphism (wild type). The two groups were compared in terms of early toxicity after transplantation, according to the preparation regimen. The group with GSTP1 polymorphism was found to have a high transferrin saturation index (P < 0.05). Patients with no GSTP1 polymorphism showed a high grade III–IV anemia ratio (P < 0.05). The presence of sinusoidal obstruction syndrome and graft–versus–host disease was similar in both groups (P > 0.05). OS and TRM were higher in the GSTP1 polymorphism group, but no statistical difference was found between the two groups (P > 0.05). Conclusions: TSI was higher in the GSTP1 polymorphism group. GSTP1 polymorphism had no effect on early transplantation complications. Although the OS and TRM ratios were higher in the GSTP1 polymorphism group, no statistically significant difference was found between the groups. Further studies with larger sample size are needed.Keywords
This publication has 45 references indexed in Scilit:
- Prognostic impact of pre-transplantation transfusion history and secondary iron overload in patients with myelodysplastic syndrome undergoing allogeneic stem cell transplantation: a GITMO studyHaematologica, 2009
- Influence of GST gene polymorphisms on busulfan pharmacokinetics in childrenBone Marrow Transplantation, 2009
- TNF,LTAandTGFB1genotype distributions among acute graft-vs-host disease subsets after HLA-matched unrelated hematopoietic stem cell transplantation: a pilot studyTissue Antigens, 2009
- Graft-versus-host diseaseThe Lancet, 2009
- Iron overload in hematopoietic cell transplantationBone Marrow Transplantation, 2008
- Prognostic impact of elevated pretransplantation serum ferritin in patients undergoing myeloablative stem cell transplantationBlood, 2007
- Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipientsBone Marrow Transplantation, 2006
- Genetic polymorphisms predicting the outcome of bone marrow transplantsBritish Journal of Haematology, 2004
- Liver disease in pediatric patients with cystic fibrosis is associated with glutathione S-transferase P1 polymorphismHepatology, 2002
- Iron overload might increase transplant-related mortality in haematopoietic stem cell transplantationBone Marrow Transplantation, 2002