Epigenetic contribution to obesity
Open Access
- 11 April 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Mammalian Genome
- Vol. 31 (5-6), 134-145
- https://doi.org/10.1007/s00335-020-09835-3
Abstract
Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), cardiovascular (CVD) and other diseases. It is a consequence of an elevated caloric intake, a sedentary lifestyle and a genetic as well as an epigenetic predisposition. This review summarizes changes in DNA methylation and microRNAs identified in blood cells and different tissues in obese human and rodent models. It includes information on epigenetic alterations which occur in response to fat-enriched diets, exercise and metabolic surgery and discusses the potential of interventions to reverse epigenetic modifications.Funding Information
- BMBF (82DZD00302)
This publication has 98 references indexed in Scilit:
- miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuitNature Communications, 2013
- Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAsProceedings of the National Academy of Sciences of the United States of America, 2011
- miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signalingProceedings of the National Academy of Sciences of the United States of America, 2011
- Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasmaProceedings of the National Academy of Sciences of the United States of America, 2011
- Mammalian microRNAs predominantly act to decrease target mRNA levelsNature, 2010
- DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specificHuman Molecular Genetics, 2009
- Biogenesis of small RNAs in animalsNature Reviews Molecular Cell Biology, 2009
- Persistent epigenetic differences associated with prenatal exposure to famine in humansProceedings of the National Academy of Sciences of the United States of America, 2008
- MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed PairingMolecular Cell, 2007
- Genomic patterns of DNA methylation: targets and function of an epigenetic markCurrent Opinion in Cell Biology, 2007