Dentate Gyrus Immaturity in Schizophrenia
- 24 January 2019
- journal article
- research article
- Published by SAGE Publications in The Neuroscientist
- Vol. 25 (6), 528-547
- https://doi.org/10.1177/1073858418824072
Abstract
Hippocampal abnormalities have been heavily implicated in the pathophysiology of schizophrenia. The dentate gyrus of the hippocampus was shown to manifest an immature molecular profile in schizophrenia subjects, as well as in various animal models of the disorder. In this position paper, we advance a hypothesis that this immature molecular profile is accompanied by an identifiable immature morphology of the dentate gyrus granule cell layer. We adduce evidence for arrested maturation of the dentate gyrus in the human schizophrenia-affected brain, as well as multiple rodent models of the disease. Implications of this neurohistopathological signature for current theory regarding the development of schizophrenia are discussed.Keywords
Funding Information
- Canadian Institutes of Health Research (MOP-68887)
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