Influence of maternal and paternal pre-conception overweight/obesity on offspring outcomes and strategies for prevention
Open Access
- 15 June 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Nutrition
- Vol. 75 (12), 1735-1744
- https://doi.org/10.1038/s41430-021-00920-7
Abstract
Overweight, obesity, and their comorbidities remain global health challenges. When established early in life, overweight is often sustained into adulthood and contributes to the early onset of non-communicable diseases. Parental pre-conception overweight and obesity is a risk factor for overweight and obesity in childhood and beyond. This increased risk likely is based on an interplay of genetic alterations and environmental exposures already at the beginning of life, although mechanisms are still poorly defined. In this narrative review, potential routes of transmission of pre-conceptional overweight/obesity from mothers and fathers to their offspring as well as prevention strategies are discussed. Observational evidence suggests that metabolic changes due to parental overweight/obesity affect epigenetic markers in oocytes and sperms alike and may influence epigenetic programming and reprogramming processes during embryogenesis. While weight reduction in overweight/obese men and women, who plan to become pregnant, seems advisable to improve undesirable outcomes in offspring, caution might be warranted. Limited evidence suggests that weight loss in men and women in close proximity to conception might increase undesirable offspring outcomes at birth due to nutritional deficits and/or metabolic disturbances in the parent also affecting gamete quality. A change in the dietary pattern might be more advisable. The data reviewed here suggest that pre-conception intervention strategies should shift from women to couples, and future studies should address possible interactions between maternal and paternal contribution to longitudinal childhood outcomes. Randomized controlled trials focusing on effects of pre-conceptional diet quality on long-term offspring health are warranted.Keywords
This publication has 110 references indexed in Scilit:
- Further evidence that culture media affect perinatal outcome: findings after transfer of fresh and cryopreserved embryosHuman Reproduction, 2012
- Bariatric Surgery Does not Interfere With Sperm Quality—A Preliminary Long-Term StudyReproductive Sciences, 2012
- Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm functionAmerican Journal of Physiology-Endocrinology and Metabolism, 2012
- Maternal weight change before pregnancy in relation to birthweight and risks of adverse pregnancy outcomesEuropean Journal of Epidemiology, 2011
- Changing perceptions of hunger on a high nutrient density dietNutrition Journal, 2010
- Associations between severity of obesity in childhood and adolescence, obesity onset and parental BMI: a longitudinal cohort studyInternational Journal of Obesity, 2010
- RAPID REPORT: Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese ratsJournal Of Physiology-London, 2010
- One-Cell Zygote Transfer from Diabetic to Nondiabetic Mouse Results in Congenital Malformations and Growth Retardation in OffspringEndocrinology, 2007
- The origins of the developmental origins theoryJournal of Internal Medicine, 2007
- Impact of Body Mass Index Values on Sperm Quantity and QualityJournal of Andrology, 2006