Substoichiometric action of long noncoding RNAs
- 13 May 2022
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 24 (5), 608-615
- https://doi.org/10.1038/s41556-022-00911-1
Abstract
Low expression levels and stoichiometric imbalances of long noncoding RNAs (lncRNAs) are often used as evidence for their probable lack of function or for limiting the scope of their potential influence. Recent advances in our understanding of the substoichiometric functions of lncRNAs challenge these notions and suggest routes through which unabundant lncRNAs can affect cellular functions and gene regulatory networks.This publication has 94 references indexed in Scilit:
- High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivationNature, 2013
- SAM Domain Polymerization Links Subnuclear Clustering of PRC1 to Gene SilencingDevelopmental Cell, 2013
- The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X ChromosomeScience, 2013
- RNA SHAPE analysis in living cellsNature Chemical Biology, 2012
- Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence EvolutionCell, 2011
- Down-Regulation of a Host MicroRNA by a Herpesvirus saimiri Noncoding RNAScience, 2010
- The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to ChromatinScience, 2008
- Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcriptionNature, 2008
- Transcriptional switches: the role of mass actionPhysics of Life Reviews, 2004
- Chromosomal silencing and localization are mediated by different domains of Xist RNANature Genetics, 2002