In the current period, with the development of economy, science, and technology, people's lives have been improved, leading to increasing demand for water use. Thus, one of the main current concerns is the increased pollution of surface water and groundwater. Especially water pollution by pesticides is a serious problem. In this study, the wastewater treated system, which is including the aerobic biological process and photocatalytic TiO2, used to evaluate the effective treatment of pesticides. Self-generated wastewater was added by a group mixed 8 types of Organochlorine pesticides (OCPs): Tetrachloro-m-xylene,b -HCH,d - HCH, Heptachlor – epoxide, 4,4'- DDE,b -Endosulfan, Endrin – aldehyde, Endosulfan – sulfate and 5 types of Organophosphate pesticides (OPPs): Diazinon, Malathion, Parathion, Ethion, Trithion. The results showed that the COD removal efficiency was over 89,09% for the whole system when maintaining the load of 0,78 kgCOD/m3. day, total retention time was 16 hours. Five types of OPPs was thoroughly treated after going through the system based on its easily biodegradable. For OCPs, the treatment efficiency through the biological process is not high, 6/8 types about 5 - 27% but through photocatalytic TiO2/UV, the treatment efficiency increased 67 - 100% for each type. The results obtained in the study show that the use of the method of combining biology and AOPs is effective for wastewater difficult to treat as pesticides.