Estimates of the effects of physical activity on osteoporosis using multivariable Mendelian randomization analysis
- 13 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Osteoporosis International
- Vol. 32 (7), 1359-1367
- https://doi.org/10.1007/s00198-020-05786-2
Abstract
Summary This study estimates causality of physical activity (PA) on bone mineral density (BMD) by conducting multivariable Mendelian randomization (MR). The findings suggest that habitual vigorous PA increases lumbar spine BMD, and higher overall acceleration average would improve forearm BMD. The results could promote PA intervention targeting individuals with optimized type. Introduction Evidence from epidemiologic studies showed type, frequency, and duration of PA influenced BMD. However, these observational studies may be confounded by many factors, resulting in spurious associations. We aimed to conduct multivariable MR to estimate the causal effect of self-reported and device-measured PA on osteoporosis. Methods Three self-reported and two device-measured PA-related traits were selected as exposures. Outcomes were BMD at different skeletal sites: femoral neck BMD (FN BMD), lumbar spine BMD (LS BMD), and forearm BMD (FA BMD). Exposure datasets were obtained from UK Biobank with total 377,234 subjects. Outcome datasets were obtained from GEFOS consortium with 53,236 subjects. Standard MR analysis and multivariable MR were conducted to assess the total and direct causal effect of PA on BMD. Results For self-reported PA, inverse-normalized moderate-to-vigorous had a direct causal effect on FN BMD independently (β = − 1.116 (95% confidence interval, 95%CI: − 2.210, − 0.023), P = 0.045); vigorous PA showed a direct effect (β = 3.592 (95%CI: 0.310, 6.874), P = 0.032) on LS BMD independently. While overall acceleration average and fraction of accelerations both had a direct causal effect on FA BMD independently. Conclusions Habitual vigorous PA could increase LS BMD. Individuals with higher overall acceleration average would have a higher FA BMD.Keywords
Funding Information
- Foundation for the National Institutes of Health (AR069055, U19 AG055373, R01 MH104680, R01AR059781 and P20GM109036)
- Science and Technology Department of Henan Province (192102310191)
This publication has 40 references indexed in Scilit:
- Examining the causal role of leptin in bone mineral density: A Mendelian randomization studyBone, 2019
- OsteoporosisThe Lancet, 2019
- Association between sleep quality and bone mineral density in Chinese women vary by age and menopausal statusSleep Medicine, 2019
- Frequency and duration of vigorous physical activity bouts are associated with adolescent boys' bone mineral status: A cross-sectional studyBone, 2018
- Burden of hip fracture using disability-adjusted life-years: a pooled analysis of prospective cohorts in the CHANCES consortiumThe Lancet Public Health, 2017
- Relationship between Bone Mineral Density and Physical Activity Level in the ElderlyAnnals of Applied Sport Science, 2015
- Physical activity and lifestyle effects on bone mineral density among young adults: sociodemographic and biochemical analysisJournal of Physical Therapy Science, 2015
- Mendelian randomization: genetic anchors for causal inference in epidemiological studiesHuman Molecular Genetics, 2014
- Correlates of physical activity: why are some people physically active and others not?The Lancet, 2012
- Medical costs of osteoporosis in the elderly Medicare populationOsteoporosis International, 2010