For decades, monkeypox virus was only a disease that infected animals but, in the 1990’s it found a new target in humans. This paper dives into the history of human monkeypox and the root of the cause right from the start. The aim here is to understand the underlying cause for the sudden rise in monkeypox cases in regions that are not conducive to the disease. Throughout the paper, there will also be a list of activities mentioned that people ought to avoid when a known person is infected. Overall, by the end of the paper there will be a clear idea of do’s and don’ts regarding monkeypox virus.