Regulation of T cell antitumor immune response by tumor induced metabolic stress
Open Access
- 14 January 2019
- journal article
- review article
- Published by Shared Science Publishers OG in Cell Stress
- Vol. 3 (1), 9-18
- https://doi.org/10.15698/cst2019.01.171
Abstract
Regulation of T cell antitumor immune response by tumor induced metabolic stress – Adaptive T cell immune response is essential for tumor growth control. The efficacy of immune checkpoint inhibitors is regulated by intratumoral immune response. The tumor microenvironment has a major role in adaptive immune response tuning. Tumor cells generate a particular metabolic environment in comparison to other tissues. Tumors are characterized by glycolysis, hypoxia, acidosis, amino acid depletion and fatty acid metabolism modification. Such metabolic changes promote tumor growth, impair immune response and lead to resistance to therapies. This review will detail how these modifications strongly affect CD8 and CD4 T cell functions and impact immunotherapy efficacy.Keywords
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