Fatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke

Abstract

Objective This tertiary analysis from A Very Early Rehabilitation Trial (AVERT) examined fatal and nonfatal serious adverse events (SAEs) at 14 days. Method AVERT was a prospective, parallel group, assessor blinded, randomized international clinical trial comparing mobility training commenced 80 years subgroups, but there was no significant treatment by subgroup interaction. No difference in nonfatal SAEs was found. Conclusion While the overall case fatality at 14 days poststroke was only 3.8%, mortality adjusted for age and stroke severity was increased with high dose and intensive training compared to usual care. Stroke progression was more common in VEM. Registration Australian New Zealand Clinical Trials Registry, ACTRN12606000185561. Classification of Evidence This study provides Class I evidence that very early mobilization increases mortality at 14 days poststroke.