Insight into Salivary Gland Aquaporins
Open Access
- 25 June 2020
- Vol. 9 (6), 1547
- https://doi.org/10.3390/cells9061547
Abstract
The main role of salivary glands (SG) is the production and secretion of saliva, in which aquaporins (AQPs) play a key role by ensuring water flow. The AQPs are transmembrane channel proteins permeable to water to allow water transport across cell membranes according to osmotic gradient. This review gives an insight into SG AQPs. Indeed, it gives a summary of the expression and localization of AQPs in adult human, rat and mouse SG, as well as of their physiological role in SG function. Furthermore, the review provides a comprehensive view of the involvement of AQPs in pathological conditions affecting SG, including Sjögren’s syndrome, diabetes, agedness, head and neck cancer radiotherapy and SG cancer. These conditions are characterized by salivary hypofunction resulting in xerostomia. A specific focus is given on current and future therapeutic strategies aiming at AQPs to treat xerostomia. A deeper understanding of the AQPs involvement in molecular mechanisms of saliva secretion and diseases offered new avenues for therapeutic approaches, including drugs, gene therapy and tissue engineering. As such, AQP5 represents a potential therapeutic target in different strategies for the treatment of xerostomia.Funding Information
- Fonds De La Recherche Scientifique - FNRS (PINT-BILAT-P-R.P006.19)
This publication has 194 references indexed in Scilit:
- Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunctionProceedings of the National Academy of Sciences of the United States of America, 2012
- Gene delivery in salivary glands: From the bench to the clinicBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2011
- Anti–Aquaporin‐4 monoclonal antibody blocker therapy for neuromyelitis opticaAnnals of Neurology, 2011
- Microchimerism in Salivary Glands after Blood- and Marrow-Derived Stem Cell TransplantationTransplantation and Cellular Therapy, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Localization of AQP5 during development of the mouse submandibular salivary glandJournal of Molecular Histology, 2011
- AAV2-mediated transfer of the human aquaporin-1 cDNA restores fluid secretion from irradiated miniature pig parotid glandsGene Therapy, 2010
- IL17: potential therapeutic target in Sjögren's syndrome using adenovirus-mediated gene transferLaboratory Investigation, 2010
- Radiotherapy for Head and Neck CancerSeminars in Plastic Surgery, 2010
- Mammalian aquaporins: diverse physiological roles and potential clinical significanceExpert Reviews in Molecular Medicine, 2008