Rapid Decay of Anti-SARS-CoV-2 Antibodies in Persons with Mild Covid-19

Abstract
Among 34 volunteers who had recovered from mild Covid-19 illness, antiviral antibodies to the receptor-binding domain of the viral spike protein declined with a mean half-life of approximately 36 days after recovery. Whether these results predict the duration of viral immunity in persons recovering from more severe cases of Covid-19 or those exposed to vaccines is unknown.
Funding Information
  • McCarthy Family Foundation
  • AIDS Healthcare Foundation (Grant to OOY)
  • National Institutes of National Institute of Allergy and Infectious Diseases (AI124979, AI131879, AI140775, UM1AI068616, UM1AI068632, UM1AI106716)
  • Doris Duke Charitable Foundation (2019086)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • National Institute of Mental Health
  • James B. Pendleton Charitable Trust