The DNA methylome of inflammatory bowel disease (IBD) reflects intrinsic and extrinsic factors in intestinal mucosal cells
Open Access
- 2 October 2020
- journal article
- research article
- Published by Taylor & Francis Ltd in Epigenetics
- Vol. 15 (10), 1068-1082
- https://doi.org/10.1080/15592294.2020.1748916
Abstract
Abnormal DNA methylation has been described in human inflammatory conditions of the gastrointestinal tract, such as inflammatory bowel disease (IBD). As other complex diseases, IBD results from the balance between genetic predisposition and environmental exposures. As such, DNA methylation may be the consequence (and potential effector) of both, genetic susceptibility variants and/or environmental signals such as cytokine exposure. We attempted to discern between these two non-excluding possibilities by performing a combined analysis of published DNA methylation data in intestinal mucosal cells of IBD and control samples. We identified abnormal DNA methylation at different levels: deviation from mean methylation signals at site and region levels, and differential variability. A fraction of such changes is associated with genetic polymorphisms linked to IBD susceptibility. In addition, by comparing with another intestinal inflammatory condition (i.e., coeliac disease) we propose that aberrant DNA methylation can also be the result of unspecific processes such as chronic inflammation. Our characterization suggests that IBD methylomes combine intrinsic and extrinsic responses in intestinal mucosal cells, and could point to knowledge-based biomarkers of IBD detection and progression.Funding Information
- Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ECTZ47287)
- Basque Department of Health (project 2018/111086)
- Ligue Contre le Cancer (AAP 2018)
- Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ECTZ50137)
- Institut National Du Cancer (PLBIO 2017)
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