MiR-210-3p Inhibits Proliferation and Migration of C6 Cells by Targeting Iscu
- 9 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Neurochemical Research
- Vol. 45 (8), 1813-1824
- https://doi.org/10.1007/s11064-020-03043-w
Abstract
Glioma is the most common primary brain tumor and the most malignant type of glioma is glioblastoma with the character of high mortality, high recurrence rate and poor prognosis. MicroRNAs act as an important component in glioma development and thus may be a potential target for the treatment of glioma. There were some researches indicated that miR-210-3p played a role in glioma development, but if it can inhibit glioma growth, as well as the underlying mechanism, is still uncertain. In the present study, we investigated the effects of miR-210-3p and its potential target gene Iscu on glioma (C6) cells proliferation and migration in vitro as well as the influence of miR-210-3p on glioma growth in vivo. The results showed that miR-210-3p inhibited the proliferation and migration of C6 cells by regulating the expression of its target gene Iscu in vitro. We also demonstrated that glioma growth was suppressed in immunodeficient mice when they were implanted with C6 cells overexpressing miR-210-3p. Our data indicated that miR-210-3p played an important role in the prevention of glioma growth by targeting Iscu and so miR-210-3p/Iscu axis might be a potential target for the treatment of glioma.Keywords
Funding Information
- Natural Science Foundation of Jiangsu Province (BK20170447)
- Undergraduate Innovation Training Program of Nantong University (2019141)
This publication has 35 references indexed in Scilit:
- CircPCMTD1 Acts as the Sponge of miR-224-5p to Promote Glioma ProgressionFrontiers in Oncology, 2019
- Therapeutic efficacy of specific immunotherapy for glioma: a systematic review and meta-analysisProgress in Neurobiology, 2018
- Antitumor activity of combined endostatin and thymidine kinase gene therapy in C6 glioma modelsCancer Medicine, 2016
- CGCG clinical practice guidelines for the management of adult diffuse gliomasCancer Letters, 2016
- Unique biology of gliomas: challenges and opportunitiesTrends in Neurosciences, 2012
- Primary brain tumours in adultsThe Lancet, 2012
- Non-coding RNAs in human diseaseNature Reviews Genetics, 2011
- MicroRNAs: Genomics, Biogenesis, Mechanism, and FunctionCell, 2004
- The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansNature, 2000
- The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Cell, 1993