Comparison of Pineal Gland Volume Between Patients with Fibromyalgia and Healthy Controls Running Title: Pgv in Fibromyalgia
Open Access
- 1 December 2022
- journal article
- research article
- Published by Pera Publishing in European Journal of Therapeutics
- Vol. 28 (4), 301-305
- https://doi.org/10.58600/eurjther-28-4-0104
Abstract
Objectives: The pineal gland is an important neuroendocrine organ accounting for the melatonin secretion and chronobiology that regulate circadian rhythm. This study was designed to compare pineal gland volume (PGV) with healthy controls and patients with fibromyalgia syndrome (FM), in which sleep quality and efficiency is reduced. Patient and Methods: In this cross-sectional study, PGV and functional pineal gland volume (FPGV) of FM patients with age- and sex-matched healthy controls were compared. All MR imaging studies were performed using a 3 Tesla scanner with a multi-channel phased array head coil. The volume of pineal glands and pineal cysts were calculated from 3D MP RAGE images using the formula: volume= AP x transverse x craniocaudal diameter x 0.523. Results: There was no significant difference in PGV and FPGV between the FM group and healthy controls (p=0.374 and p=0.421, respectively). In the correlation analysis, age was negatively correlated with PGV and FPGV in the FM group (r=-0.496, p=0.010; r=-0.477, p=0.014, respectively). No significant correlation was detected between age, PGV and FPGV in the control group (r= 0.022, p=0.916; r= -0.019, p=0.925, respectively). Conclusions: Based on the results, there was no significant difference between the FM group and healthy controls regarding PGV and FPGV. However, PGV and FPGV were decreased by advancing age in the FM group in which melatonin therapy is offered as an option.Keywords
This publication has 13 references indexed in Scilit:
- Association between dietary insulin index and load with obesity in adultsEuropean Journal of Nutrition, 2019
- Management of Type 2 Diabetes Mellitus with Overweight: Focus on SGLT-2 Inhibitors and GLP-1 Receptor AgonistsEuropean Journal of Therapeutics, 2019
- Associations between dietary insulin load with cardiovascular risk factors and inflammatory parameters in elderly men: a cross-sectional studyBritish Journal of Nutrition, 2019
- Effects of Nutrition and Exercise Habits in Patients with Type 2 DiabetesEuropean Journal of Therapeutics, 2018
- Knowledge levels and attitudes of diabetic patients about their diseaseEuropean Journal of Therapeutics, 2018
- Dietary insulin load and insulin index are associated with the risk of insulin resistance: a prospective approach in tehran lipid and glucose studyJournal of Diabetes & Metabolic Disorders, 2015
- Estimating insulin demand for protein-containing foods using the food insulin indexEuropean Journal of Clinical Nutrition, 2014
- Prospective associations of dietary insulin demand, glycemic index, and glycemic load during puberty with body composition in young adulthoodInternational Journal of Obesity, 2012
- Dietary insulin index and insulin load in relation to biomarkers of glycemic control, plasma lipids, and inflammation markersThe American Journal of Clinical Nutrition, 2011
- Food insulin index: physiologic basis for predicting insulin demand evoked by composite mealsThe American Journal of Clinical Nutrition, 2009