Measurement of Health-Related Quality of Life Among Colorectal Cancer Patients Using the Vietnamese Value Set of the EQ-5D-5L
Open Access
- 1 January 2020
- journal article
- research article
- Published by Taylor & Francis Ltd in Patient Preference and Adherence
- Vol. 14, 2427-2437
- https://doi.org/10.2147/PPA.S281500
Abstract
Purpose: Health-related quality of life (HRQoL) is an important construct in clinical settings, and it is crucial that it should be properly measured. As the EuroQol-5-dimensions-5 levels (EQ-5D-5L) is more effective for such measurement than the 3-level model, data on economic models, clinical studies, and public health evaluations previously collected through the EQ-5D-3L need to be revaluated using the EQ-5D-5L. This study evaluated colorectal cancer (CRC) patients' HRQoL scores using the Vietnamese EQ-5D-5L value set. Patients and Methods: The cross-sectional study included CRC patients treated at a tertiary public hospital. HRQoL was assessed using the EQ-5D-5L, and HRQoL utility scores were calculated using the Vietnamese value set. Tobit regression examined factors associated with HRQoL. Results: The analysis included 197 CRC patients. Ages ranged from 20 to 87 years (M = 57.64, SD = 13.5); 42.2% and 57.8% were diagnosed with cancer of the colon or rectum/ anus, respectively. Mean EQ-5D-5L was 0.561 (range, -0.5115 to 1). Most participants experienced anxiety/depression (88%), followed by pain/discomfort (87%), mobility (71%), usual activity (69%), and self-care (67%). Advanced CRC stage (stage II: beta -0.303, se 0.08; stage III: beta -0.305, se 0.07; stage IV: beta -0.456, se 0.07) and surgery (beta -0.113, se 0.05) were negatively associated with EQ-5D-5L scores. Advanced education (high school: beta 0.273, se 0.07); college/vocational: beta 0.134se 0.05; university/higher: Coef 0.213, se 0.08;) and older age (age group 35-44: beta 0.253, se 0.10; 45-54: beta 0.327, se 0.09; 55-64: beta 0.355 se 0.09; 65+ beta 0.204, se 0.09) were positively associated with EQ-5D-5L scores. Conclusion: Patients in advanced CRC stages or undergoing surgery experienced lower HRQoL and higher prevalence of anxiety/depression and pain/discomfort. Older age and high educational attainment predicted high HRQoL. This study provides information on CRC patients' health utility based on various patient characteristics, which can be used in future economic evaluations.This publication has 37 references indexed in Scilit:
- Health-related quality of life and life satisfaction in colorectal cancer survivors: trajectories of adjustmentHealth and Quality of Life Outcomes, 2013
- Clinical Correlates of Health Preference and Generic Health-Related Quality of Life in Patients with Colorectal NeoplasmsPLOS ONE, 2013
- Validity and reliability of the EQ-5D for cancer patients in KoreaSupportive Care in Cancer, 2012
- A five-year prospective study of quality of life after colorectal cancerQuality of Life Research, 2011
- Comparing the psychometric properties of the EQ-5D-3L and EQ-5D-5L in cancer patients in KoreaQuality of Life Research, 2011
- Utility values in National Institute for Health and Clinical Excellence (NICE) Technology AppraisalsValue in Health, 2011
- Longitudinal tobit regression: A new approach to analyze outcome variables with floor or ceiling effectsJournal of Clinical Epidemiology, 2009
- Quality of Life Among Disease-Free Survivors of Rectal CancerJournal of Clinical Oncology, 2004
- Socioeconomic status and stage at presentation of colorectal cancerThe Lancet, 1998
- Quality of life in adult survivors of lung, colon and prostate cancerQuality of Life Research, 1994