The Drosophila Model: Exploring Novel Therapeutic Compounds against Neurodegenerative Diseases
Open Access
- 6 December 2019
- journal article
- review article
- Published by MDPI AG in Antioxidants
- Vol. 8 (12), 623
- https://doi.org/10.3390/antiox8120623
Abstract
Polyphenols are secondary metabolites of plants, fruits, and vegetables. They act as antioxidants against free radicals from UV light, pathogens, parasites, and oxidative stress. In Drosophila models, feeding with various polyphenols results in increased antioxidant capacity and prolonged lifespan. Therefore, dietary polyphenols have several health advantages for preventing many human diseases, including cardiovascular diseases, cancer, and neurodegenerative diseases. However, the exact role of polyphenols in neurodegenerative diseases is still yet to be completely defined. This review focuses on the most recent studies related to the therapeutic effect of polyphenols in neurodegenerative disease management and provides an overview of novel drug discovery from various polyphenols using the Drosophila model.Funding Information
- The Ministry of Education (MOE) Korea (2019R1F1A1045639)
- Soonchunhyang University (2019)
This publication has 81 references indexed in Scilit:
- BET inhibition as a single or combined therapeutic approach in primary paediatric B-precursor acute lymphoblastic leukaemiaBlood Cancer Journal, 2013
- Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic DiseasesAntioxidants and Redox Signaling, 2013
- Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonismNeurobiology of Disease, 2013
- Curcumin and neurodegenerative diseasesBioFactors, 2013
- Tangeretin, a citrus flavonoid, inhibits PGDF-BB-induced proliferation and migration of aortic smooth muscle cells by blocking AKT activationEuropean Journal of Pharmacology, 2011
- Priorities in Parkinson's disease researchNature Reviews Drug Discovery, 2011
- Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer PropertiesMolecules, 2010
- Potential application of grape derived polyphenols in Huntington’s diseaseTranslational Neuroscience, 2010
- Effects of Grape Seed-derived Polyphenols on Amyloid β-Protein Self-assembly and Cytotoxicity*Online Journal of Public Health Informatics, 2008
- Grape-Derived Polyphenolics Prevent A Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's DiseaseJournal of Neuroscience, 2008