Rubinstein- Taybi Syndrome is a congenital malformation involving multiple organs of the body. Several etiologies have been proposed for this multisystem disorder like mutations in the CREBBP gene, EP300 gene, deletion of genetic material from the short arm of chromosome 16. It is characterized by unique features like mental retardation, craniofacial abnormalities like beaked nose, microcephaly, hypertelorism, broad nasal bridge etc. Further, involvement of renal, cardiac, auditory, respiratory, immunologic, endocrine, bone involvement and tumors have been illustrated in the literature. But literature search on oral manifestations are few. So this manuscript sketches the etiopathogenesis, clinical features, management of this disorder with the special focus on orodental manifestation reported in the literature review.