Impact of exercise on the immune system and outcomes in hematologic malignancies
Open Access
- 28 April 2020
- journal article
- review article
- Published by American Society of Hematology in Blood Advances
- Vol. 4 (8), 1801-1811
- https://doi.org/10.1182/bloodadvances.2019001317
Abstract
Exercise is increasingly recognized as important to cancer care. The biology of how exercise improves outcomes is not well understood, however. Studies show that exercise favorably influences the immune system in healthy individuals (neutrophils, monocytes, natural killer cells, T cells, and a number of cytokines). Thus, exercise in patients with hematologic cancer could significantly improve immune function and tumor microenvironment. We performed a literature search and identified 7 studies examining exercise and the immune environment in hematologic malignancies. This review focuses on the role of exercise and physical activity on the immune system in hematologic malignancies and healthy adults.This publication has 112 references indexed in Scilit:
- Inhibition of Glycogen Synthase Kinase-3 Increases NKG2D Ligand MICA Expression and Sensitivity to NK Cell–Mediated Cytotoxicity in Multiple Myeloma Cells: Role of STAT3The Journal of Immunology, 2013
- Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic ImplicationsJournal of Immunology Research, 2012
- Physical Activity, Biomarkers, and Disease Outcomes in Cancer Survivors: A Systematic ReviewJNCI Journal of the National Cancer Institute, 2012
- Natural killer cells: role in local tumor growth and metastasisBiologics: Targets and Therapy, 2012
- Severe Exercise and Exercise Training Exert Opposite Effects on Human Neutrophil Apoptosis via Altering the Redox StatusPLOS ONE, 2011
- Quality of life assessment as a predictor of survival in non-small cell lung cancerBMC Cancer, 2011
- Physical activity for patients undergoing an allogeneic hematopoietic stem cell transplantation: benefits of a moderate exercise interventionEuropean Journal of Haematology, 2011
- The relationship between quality of life (EORTC QLQ-C30) and survival in patients with gastro-oesophageal cancerBritish Journal of Cancer, 2008
- Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapySupportive Care in Cancer, 2003
- Effects of Exercise and Training on Natural Killer Cell Counts and Cytolytic ActivitySports Medicine, 1999