Clinical characteristics and outcomes of critically ill patients with acute COVID-19 with Epstein-Barr virus reactivation
Open Access
- 15 September 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Infectious Diseases
- Vol. 21 (1), 1-8
- https://doi.org/10.1186/s12879-021-06638-y
Abstract
Our goal is to further elucidate the clinical condition and prognosis of patients with severe acute COVID-19 with EBV reactivation. This is a retrospective single-center study of COVID-19 patients admitted to the intensive care unit of Wuhan No. 3 Hospital (January 31 to March 27, 2020). According to whether Epstein-Barr virus reactivation was detected, the patients were divided into an EBV group and a Non-EBV group. Baseline data were collected including epidemiological, larithmics, clinical and imaging characteristics, and laboratory examination data. Of the 128 patients with COVID-19, 17 (13.3%) were infected with Epstein-Barr virus reactivation. In the symptoms,the rate of tachypnoea in the EBV group was apparently higher than that in the Non-EBV group. In lab tests, the lymphocyte and albumin of EBV group decreased more significantly than Non-EBV group, and the D-dimer and serum calcium of EBV group was higher than Non-EBV group. Regarding the infection index, CRP of EBV group was apparently above the Non-EBV group, and no significant difference was found in procalcitonin of the two groups. The incidence of respiratory failure, ARDS, and hypoproteinaemia of EBV group had more incidence than Non-EBV group. The 28-day and 14-day mortality rates of EBV group was significantly higher than that of Non-EBV group. In the COVID-19 patients, patients with EBV reactivation had higher 28-day and 14-day mortality rates and received more immuno-supportive treatment than patients of Non-EBV group.This publication has 15 references indexed in Scilit:
- Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational studyThe Lancet Respiratory Medicine, 2020
- A Familial Cluster of Infection Associated With the 2019 Novel Coronavirus Indicating Possible Person-to-Person Transmission During the Incubation PeriodThe Journal of Infectious Diseases, 2020
- Pig as a reservoir of CRISPR type TST4 Salmonella enterica serovar Typhimurium monophasic variant during 2009–2017 in ChinaEmerging Microbes & Infections, 2019
- Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: A prospective cohort studyBrain, Behavior, and Immunity, 2018
- C-Reactive Protein/Albumin Ratio (CAR) as a Prognostic Factor in Patients with Non-Metastatic Nasopharyngeal CarcinomaJournal of Cancer, 2016
- Epstein-Barr Virus Latent Membrane Protein 1 Increases Calcium Influx through Store-operated Channels in B Lymphoid CellsOnline Journal of Public Health Informatics, 2011
- Proposed guidelines for diagnosing chronic active Epstein‐Barr virus infectionAmerican Journal of Hematology, 2005
- Significant Changes of Peripheral T Lymphocyte Subsets in Patients with Severe Acute Respiratory SyndromeThe Journal of Infectious Diseases, 2004
- [Clinical features and therapy of 106 cases of severe acute respiratory syndrome].2003