Tumour budding and tumour–stroma ratio in hepatocellular carcinoma
Open Access
- 4 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 123 (1), 38-45
- https://doi.org/10.1038/s41416-020-0847-1
Abstract
Background Tumour budding and low tumour–stroma ratio (TSR) are associated with poor prognosis in some cancers, but their value in Western hepatocellular carcinoma is unclear. The prognostic value of tumour budding and TSR in hepatocellular carcinoma was examined. Methods Some 259 hepatocellular carcinoma patients treated in Oulu University Hospital 1983–2018 were included in this retrospective cohort study. Tumour budding and TSR were analysed from the haematoxylin- and eosin-stained original diagnostic slides, by dividing patients into bud-negative (0 bud) or bud-positive (≥1 bud) groups, and into high TSR (n = 47) and other treatments (n = 212) were analysed separately. Primary outcomes were overall, and disease-specific 5-year mortality was adjusted for confounding factors. Results Surgically treated patients with positive tumour budding had increased 5-year overall (adjusted HR 3.87, 95% CI 1.10–13.61) and disease-specific (adjusted HR 6.17, 95% CI 1.19–31.90) mortality compared with bud-negative patients. In surgically treated patients, TSR had no effect on 5-year overall (adjusted HR 2.03, 95% CI 0.57–7.21) or disease-specific (adjusted HR 3.23, 95% CI 0.78–13.37) mortality. No difference in survival related to tumour budding and TSR in non-surgically treated patients was observed. Conclusions Tumour budding is a prognostic factor in surgically treated hepatocellular carcinoma.Keywords
Funding Information
- Suomen Lääketieteen Säätiö
- Instrumentariumin Tiedesäätiö
This publication has 37 references indexed in Scilit:
- Alcoholic Liver Disease: Pathogenesis and New Therapeutic TargetsGastroenterology, 2011
- Tumor–stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patientsBreast Cancer Research and Treatment, 2010
- The stromal part of adenocarcinomas of the oesophagus: Does it conceal targets for therapy?European Journal of Cancer, 2010
- Multivariate Analysis of the Pathologic Features of Esophageal Squamous Cell Cancer: Tumor Budding Is a Significant Independent Prognostic FactorAnnals of Surgical Oncology, 2008
- Hepatocellular Carcinoma: Epidemiology and Molecular CarcinogenesisGastroenterology, 2007
- Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical OutcomeScience, 2006
- Tumor budding as a useful prognostic marker in esophageal squamous cell carcinomaDiseases of the Esophagus, 2004
- Budding Is Useful to Select High-Risk Patients in Stage II Well-Differentiated or Moderately Differentiated Colon AdenocarcinomaDiseases of the Colon & Rectum, 2003
- Role of tissue stroma in cancer cell invasionThe Journal of Pathology, 2003
- Prognostic value of tumor “budding” in patients with colorectal cancerDiseases of the Colon & Rectum, 1993