Anti-inflammatory constituents from Phyllostachys makinoi Hayata
- 14 February 2021
- journal article
- research article
- Published by Informa UK Limited in Natural Product Research
- Vol. 36 (6), 1425-1432
- https://doi.org/10.1080/14786419.2021.1885406
Abstract
A novel chromone analogue, phyllomakin A (1), and a new flavonolignan, (-)-quiquelignan C (2), along with 18 phenolic and 2 triterpenoids, were isolated from the leaves of Phyllostachys makinoi Hayata. The structures of 1–22 were elucidated by an application of various spectroscopic analyses (1D & 2D NMR and MS) and compared with reported data. A biological evaluation showed that compound 3 had very potent anti-NO production activity (IC50 = 4.80 µM), while compounds 2, 6, 11, and 15 showed moderate inhibitory effects (IC50 = 10.19, 13.26, 13.56, and 10.96 µM, respectively) without affecting cell viability at 20 μM. Graphical AbstractKeywords
Funding Information
- Ministry of Health and Welfare Taiwan (MM10701-0117, MOHW108-NRICM-B-315-144002)
- The Ministry of Sciences and Technology (MOST 105-2320-B-077-001-MY2)
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