CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function
Open Access
- 13 November 2020
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Immunology Research
- Vol. 9 (1), 62-74
- https://doi.org/10.1158/2326-6066.cir-20-0253
Abstract
CD28 mutations enhance CAR T-cell function by reducing expression of transcription factors such as NFAT and NUR77, which in turn reduce expression of exhaustion-related genes. These data highlight considerations for CAR design that could improve antitumor responses.Keywords
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Funding Information
- NCI (P30-CA076292)
- Moffitt Cancer Center (P30-CA076292)
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