Individual shear rate therapy (ISRT)—further development of external counterpulsation for decreasing blood pressure in patients with symptomatic coronary artery disease (CAD)
- 23 December 2019
- journal article
- research article
- Published by Springer Science and Business Media LLC in Hypertension Research
- Vol. 43 (3), 186-196
- https://doi.org/10.1038/s41440-019-0380-x
Abstract
Individual shear rate therapy (ISRT) evolved from external counterpulsation with individual treatment pressures based on Doppler ultrasound measurements. In this study, we assessed the effect of ISRT on blood pressure (BP) in patients with coronary artery disease (CAD). Eighty-four patients with symptomatic CAD were included in the study. Forty-one patients were enrolled for 6 weeks, comprising 30 sessions of ISRT; 43 age- and sex-matched patients represented the control group. The 24-h BP was determined by measuring the pulse transit time before and after 6 weeks of ISRT or the time-matched control. Participants were divided into three groups according to the 24-h BP before treatment: BP1 < 130/80 mmHg (normotensive); BP2 ≥ 130–140/80 mmHg (moderate hypertensive); BP3 > 140/80 mmHg (hypertensive). After 30 sessions of ISRT, the 24-h BP decreased significantly, whereas no changes were observed in the controls. The BP-lowering effect correlated with the 24-h BP before therapy (systolic: r = −0.78; p < 0.001; diastolic: r = −0.76; p < 0.001). In BP1, the systolic BP decreased by 4.3 ± 6.4 mmHg (p = 0.011), and the diastolic BP decreased by 4.8 ± 11.0 mmHg (p = 0.032); in BP2, the systolic BP decreased by 13.3 ± 7.5 mmHg (p < 0.001), and the diastolic BP decreased by 5.0 ± 7.5 mmHg (p = 0.002); and in BP3, the systolic BP decreased by 22.9 ± 11.4 mmHg (p < 0.001), and the diastolic BP decreased by 9.1 ± 9.5 mmHg (p = 0.003). Our findings demonstrate that ISRT reduces BP in patients with CAD. The higher the initial BP the greater the lowering effect.Keywords
This publication has 30 references indexed in Scilit:
- External Counterpulsation Augments Blood Pressure and Cerebral Flow Velocities in Ischemic Stroke Patients With Cerebral Intracranial Large Artery Occlusive DiseaseStroke, 2012
- Advances in Health Policy and Outcome 2010–2011Stroke, 2012
- Effects of Enhanced External Counterpulsation on Arterial Stiffness and Myocardial Oxygen Demand in Patients With Chronic Angina PectorisThe American Journal of Cardiology, 2011
- Validierung der kontinuierlichen nicht-invasiven Blutdruckmessung mittels Puls-Transit-ZeitDeutsche Medizinische Wochenschrift (1946), 2010
- Enhanced External Counterpulsation Improves Peripheral Artery Flow-Mediated Dilation in Patients With Chronic AnginaCirculation, 2010
- Effects on blood pressure in patients with refractory angina pectoris after enhanced external counterpulsationBlood Pressure, 2010
- Enhanced external counterpulsation improves systolic blood pressure in patients with refractory anginaAmerican Heart Journal, 2008
- 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)European Heart Journal, 2006
- Enhanced External Counterpulsation Improves Exercise Duration and Peak Oxygen Consumption in Older Patients With Heart Failure: A Subgroup Analysis of the PEECH TrialCongestive Heart Failure, 2006
- Vascular Endothelial Growth Factor-Induced Nitric Oxide- and PGI2-Dependent Relaxation in Human Internal Mammary ArteriesJournal of Cardiovascular Pharmacology, 2004