Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma
- 1 July 2020
- journal article
- research article
- Published by American Society of Neuroradiology (ASNR) in American Journal of Neuroradiology
- Vol. 41 (7), 1156-1159
- https://doi.org/10.3174/ajnr.A6583
Abstract
Sinonasal inverted papillomas occasionally undergo malignant transformation into squamous cell carcinoma, which can be associated with EGFR mutations. Since biopsy can potentially under-sample the tumor, CT and MRI can provide clues as to the presence of malignant transformation. In particular, this entity tends to appear different from benign inverted papilloma on imaging, including prominent bone erosions, necrosis, low diffusivity in the solid tumor components, and absence of the cerebriform pattern on MRI. The radiology findings, pathology features, and management of squamous cell carcinoma arising from inverted papilloma are described.This publication has 13 references indexed in Scilit:
- Imaging predictors for malignant transformation of inverted papillomaThe Laryngoscope, 2018
- Comprehensive analysis of HPV infection, EGFR exon 20 mutations and LINE1 hypomethylation as risk factors for malignant transformation of sinonasal‐inverted papilloma to squamous cell carcinomaInternational Journal of Cancer, 2018
- Clinical features of nasal and sinonasal inverted papilloma associated with malignancyAuris Nasus Larynx, 2018
- Human papillomavirus (HPV) and somatic EGFR mutations are essential, mutually exclusive oncogenic mechanisms for inverted sinonasal papillomas and associated sinonasal squamous cell carcinomasAnnals of Oncology, 2017
- Prediction of the originating site of sinonasal inverted papilloma by preoperative magnetic resonance imaging and computed tomographyInternational Forum of Allergy & Rhinology, 2016
- Clinical management of squamous cell carcinoma associated with sinonasal inverted papillomaAuris Nasus Larynx, 2016
- High-Frequency Targetable EGFR Mutations in Sinonasal Squamous Cell Carcinomas Arising from Inverted Sinonasal PapillomaCancer Research, 2015
- Sinonasal carcinoma associated with inverted papilloma: a report of 16 casesJournal of Cranio-Maxillofacial Surgery, 2012
- Risks of malignancy in inverted papilloma of the nose and paranasal sinusesCurrent Opinion in Otolaryngology & Head and Neck Surgery, 2007
- Magnetic Resonance Imaging Findings of Inverted Papilloma: Differential Diagnosis with Malignant Sinonasal TumorsAmerican Journal of Rhinology, 2004