The Role of Proteostasis Derailment in Cardiac Diseases
Open Access
- 19 October 2020
- Vol. 9 (10), 2317
- https://doi.org/10.3390/cells9102317
Abstract
The incidence and prevalence of cardiac diseases, which are the main cause of death worldwide, are likely to increase because of population ageing and changes in lifestyle. Prevailing theories about the mechanisms of cardiac disease onset feature the gradual derailment of cellular protein homeostasis (proteostasis) and loss of the protein quality control as central factors. In the heart, loss of protein patency, due to flaws in design (genetically) or environmentally-induced wear and tear, may overwhelm protein quality control, thereby triggering derailment of proteostasis and contributing to cardiac disease onset.This publication has 14 references indexed in Scilit:
- ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the HeartCells, 2020
- Daily Supplementation of L-Glutamine in Atrial Fibrillation Patients: The Effect on Heat Shock Proteins and MetabolitesCells, 2020
- Is Desmin Propensity to Aggregate Part of its Protective Function?Cells, 2020
- SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent AutophagyCells, 2020
- Oral geranylgeranylacetone treatment increases heat shock protein expression in human atrial tissueHeart Rhythm, 2020
- Imbalance of ER and Mitochondria Interactions: Prelude to Cardiac Ageing and Disease?Cells, 2019
- Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial FibrillationCells, 2019
- Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic CardiomyopathyCells, 2019
- Proteostasis in cardiac health and diseaseNature Reviews Cardiology, 2017
- Induction of Heat Shock Response Protects the Heart Against Atrial FibrillationCirculation Research, 2006