Is antibiotics prescription needed in infants with topical corticosteroids treatment for moderate‐to‐severe atopic dermatitis?
- 22 August 2020
- journal article
- research article
- Published by Hindawi Limited in Dermatologic Therapy
- Vol. 33 (6), e14215
- https://doi.org/10.1111/dth.14215
Abstract
Background The cutaneous microbiota responses to skin health as well as atopic dermatitis Objectives To reveal the microbiota effect in atopic dermatitis children under therapy with topical corticosteroids and antibiotics Materials & Methods 59 atopic dermatitis patients were randomized to two treatment groups (by corticosteroids or combination therapy) in Beijing Children's Hospital. The lesion microbial samples were collected for 16S rDNA sequencing and bioinformatics analysis Results After treatment, 57 patients recovered significantly. Though topical antibiotics application blocked the restoration of commensal Streptococcus, no remarkable differences of cutaneous microbiota were identified between the two groups along the treatment. In subject 1081, who received the combination therapy, the Streptococcus and Pseudomonas as well as Chryseobacterium increased dramatically. On the contrary, the Staphylococcus aureus decreased sharply in subject 1107 with topical corticosteroids treatment Conclusion Our preliminary study suggested the necessity to consider cutaneous microbiota profile when prescribing antibiotics.Keywords
Funding Information
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201601)
- National Institutes of Health (CA008748)
- National Natural Science Foundation of China (81673042)
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