Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence
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Open Access
- 26 January 2021
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 11 (6), 1542-1561
- https://doi.org/10.1158/2159-8290.cd-20-1375
Abstract
Following patient treatment with chemotherapy, surviving acute myeloid leukemia cells adopted a senescent-like state—distinct from previously described stem cell–like states—that enabled them to drive relapse.Keywords
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Funding Information
- NIH NCI (R01CA198089)
- NIH NCI (CA233332)
- NIH (R01 CA050947)
- NIH (CA196664)
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