A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes
Open Access
- 6 January 2021
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Discovery
- Vol. 11 (5), 1138-1157
- https://doi.org/10.1158/2159-8290.cd-20-0537
Abstract
The presence of the colon-dwelling microbe Bacteroides fragilis in the gut or breast duct was associated with breast tumorigenesis, and a toxin produced by enterotoxigenic B. fragilis promoted an invasive, migratory, stemlike phenotype in breast cancer cells.Keywords
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Funding Information
- NCI NIH (R01CA204555)
- Breast Cancer Research Foundation (90047965)
- NCI NIH (CA183804)
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