Impact of Percutaneous Edge-to-Edge Repair in Patients With Atrial Functional Mitral Regurgitation
Open Access
- 25 June 2021
- journal article
- research article
- Published by Japanese Circulation Society in Circulation Journal
- Vol. 85 (7), 1001-1010
- https://doi.org/10.1253/circj.cj-20-0971
Abstract
Background:The aim of this study was to clarify the clinical outcomes of patients with atrial functional mitral regurgitation (FMR) who underwent the MitraClip procedure compared with those with conventional FMR and sinus rhythm (SR). Methods and Results:Of 303 patients with FMR who underwent the MitraClip procedure, 40 with “atrial-FMR” defined as FMR with permanent atrial fibrillation and normal left ventricular (LV) function/size and 115 with “sinus-FMR” defined as FMR with SR and LV dysfunction were reviewed. Transthoracic and 3D transesophageal echocardiography, and the cardiac complication rate (composite of all-cause death, heart failure admission, mitral valve (MV) surgery, and redo MitraClip procedure) during the 12-month follow-up were compared between the groups. After the MitraClip procedure, reductions in the mitral annular area and its anteroposterior dimension and in the leaflet closure area were observed in both groups. MV orifice area was smaller with greater transmitral pressure gradient (PConclusions:Reduction of MR occurred in atrial-FMR probably because of the increase in leaflet coaptation area. Significant TR was more common after the MitraClip procedure in patients with atrial-FMR than with sinus-FMR. However, mid-term outcomes were comparable between patients with atrial-FMR and sinus-FMR.Keywords
This publication has 18 references indexed in Scilit:
- Insufficient Leaflet Remodeling in Patients With Atrial FibrillationCirculation: Cardiovascular Imaging, 2017
- Comparison of Tricuspid Annular Plane Systolic Excursion in Patients With Atrial Fibrillation Versus Sinus RhythmThe American Journal of Cardiology, 2015
- Secondary Mitral Regurgitation in Heart FailureJournal of the American College of Cardiology, 2015
- Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular ImagingJournal of the American Society of Echocardiography, 2015
- Updated standardized endpoint definitions for transcatheter aortic valve implantation: The Valve Academic Research Consortium-2 consensus documentThe Journal of Thoracic and Cardiovascular Surgery, 2013
- Analysis of Procedural Effects of Percutaneous Edge-to-Edge Mitral Valve Repair by 2D and 3D EchocardiographyCirculation: Cardiovascular Imaging, 2012
- Evidence of Atrial Functional Mitral Regurgitation Due to Atrial Fibrillation: Reversal With Arrhythmia ControlJournal of the American College of Cardiology, 2011
- The Acute Hemodynamic Effects of MitraClip TherapyJournal of the American College of Cardiology, 2011
- Percutaneous Repair or Surgery for Mitral RegurgitationThe New England Journal of Medicine, 2011
- Brain natriuretic peptide is elevated in outpatients with atrial fibrillationThe American Journal of Cardiology, 2003