Synthesis and characterization of new imidazolidineiminothione and bis-imidazolidineiminothione derivatives as potential antimicrobial agents
Open Access
- 31 March 2017
- journal article
- Published by European Journal of Chemistry in European Journal of Chemistry
- Vol. 8 (1), 76-81
- https://doi.org/10.5155/eurjchem.8.1.76-81.1542
Abstract
A series of new imidazolidineiminothiones (2-4) and bis-imidazolidineiminothiones (5) were synthesized through the cycloaddition reaction of N-arylcyanothioformamides (1) with some electrophilic reagents. Structure of imidazolidineiminothione derivatives were established based on spectroscopic IR, 1H NMR, 13C NMR, MS and elemental analyses data. These compounds were screened for their antibacterial and antifungal activities. Among the synthesized compounds, imidazolidineiminothione derivative 3a showed about 25% less potent effect than Ampicillin against S. epidermidis and B. subtilis (MIC, 0.49 μg/mL) and about 50 % less potent effect than Amphotericin B against A. clavatus and G. Candidum. Bis-imidazolidineiminothione derivative 5a was equipotent to the Gentamycin in inhibiting the growth of N. gonorrhoeae (MIC, 0.49 μg/mL), and displayed 50% less active than Amphotericin B against A. clavatus.Keywords
This publication has 14 references indexed in Scilit:
- New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activitiesEuropean Journal of Medicinal Chemistry, 2016
- New 1,3-diaryl-5-thioxo-imidazolidin-2,4-dione derivatives: synthesis, reactions and evaluation of antibacterial and antifungal activitiesZeitschrift für Naturforschung B, 2016
- New Imidazolidineiminothione, Imidazolidin-2-one and Imidazoquinoxaline Derivatives: Synthesis and Evaluation of Antibacterial and Antifungal ActivitiesCurrent Organic Synthesis, 2016
- Synthesis and Antimicrobial Activity of Furochromone, Benzofuran and Furocoumarin Derivatives Bearing Sulfonyl MoietyCroatica Chemica Acta, 2016
- Thiourea derivatives incorporating a hippuric acid moiety: Synthesis and evaluation of antibacterial and antifungal activitiesEuropean Journal of Medicinal Chemistry, 2013
- Synthesis and characterization of new types of 2-(6-methoxy-2-naphthyl)propionamide derivatives as potential antibacterial and antifungal agentsMedicinal Chemistry Research, 2013
- Synthesis, characterization, and derivatization of some novel types of fluorinated mono- and bis-imidazolidineiminothiones with antitumor, antiviral, antibacterial, and antifungal activitiesJournal of Fluorine Chemistry, 2011
- Synthesis, characterization and derivatization of some novel types of mono- and bis-imidazolidineiminothiones and imidazolidineiminodithiones with antitumor, antiviral, antibacterial and antifungal activities – part IEuropean Journal of Medicinal Chemistry, 2009
- New Types of Mono and Bis Sulfonamides, Tosylamino Acids and Thiosulfonic Ester Derived from Xanthotoxin, Bergapten and Visnagin with Biological InterestPhosphorus, Sulfur, and Silicon and the Related Elements, 2007
- Synthesis and .alpha.2-adrenoceptor effects of substituted catecholimidazoline and catecholimidazole analogs in human plateletsJournal of Medicinal Chemistry, 1990