Study on depressive symptoms in patients with Mayer-Rokitansky-Küster-Hauser syndrome: an analysis of 141 cases
Open Access
- 24 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Orphanet Journal of Rare Diseases
- Vol. 15 (1), 1-9
- https://doi.org/10.1186/s13023-020-01405-9
Abstract
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital disease characterized by uterovaginal agenesis. The diagnosis of MRKH syndrome generally leads to considerable emotional burdens on patients. However, studies focusing on the psychological influence on patients are limited and of unsatisfactory quality. The aim of this study was to investigate the prevalence of depressive symptoms in Chinese patients with MRKH syndrome and to identify the factors associated with depressive symptoms. We recruited 141 patients with MRKH syndrome and 178 age-matched healthy women as control group in this cross-sectional study. Depressive symptoms were assessed by the Patient Health Questionnaire-9 (PHQ-9). Other parameters such as sociodemographic characteristics, treatment histories, personality traits, and attitudes toward femininity and offspring, were also gathered in the self-administered questionnaire. The PHQ-9 score was significantly higher in MRKH patient group than the age-matched control group (7.0 (4.5–11.0) vs. 6.0 (3.0–9.0)), median and IQRs) (P = 0.015). A total of 75.2% of MRKH patients suffered from depressive symptoms, and 34.0% reached a moderate to severe level, while the proportion in the control group was 61.2 and 24.2% respectively. Compared with other age groups, patients in their 20s scored higher on the PHQ-9. Patients with higher neuroticism levels in personality traits (OR 1.19 95% CI 1.11–1.28), negative self-evaluation of femininity (OR 3.964, 95% CI 1.371–11.464) and sexual dysfunction (OR 4.81 95% CI 1.24–18.72) (compared with those having no sexual activity) were more likely to exhibit depressive symptoms. Three-quarters of MRKH patients show depressive symptoms, and one-third of these individuals are even at risk for depressive disorders. Therefore, depressive symptom screening and proper psychotherapy in MRKH patients are of great importance.Keywords
Funding Information
- National Science Foundation for Youth (81801401)
This publication has 25 references indexed in Scilit:
- Female Orgasm and Overall Sexual Function and Habits: A Descriptive Study of a Cohort of U.S. WomenThe Journal of Sexual Medicine, 2020
- Treatment of vaginal agenesis in Mayer-Rokitansky-Küster-Hauser syndrome in Denmark: a nationwide comparative study of anatomical outcome and complicationsFertility and Sterility, 2018
- ACOG Committee Opinion No. 728: Müllerian Agenesis: Diagnosis, Management, And TreatmentObstetrics & Gynecology, 2018
- The Lived Experience of MRKH: Sharing Health Information with PeersJournal of Pediatric and Adolescent Gynecology, 2015
- A diagnostic meta-analysis of the Patient Health Questionnaire-9 (PHQ-9) algorithm scoring method as a screen for depressionGeneral Hospital Psychiatry, 2015
- Reliability and validity of the Chinese version of the Patient Health Questionnaire (PHQ-9) in the general populationGeneral Hospital Psychiatry, 2014
- Emotional and sexual wellness and quality of life in women with Rokitansky syndromeAmerican Journal of Obstetrics and Gynecology, 2011
- Sexuality and Psychosocial Functioning in Young Women After ColovaginoplastyJournal of Urology, 2010
- Psychological Distress in Women With Uterovaginal Agenesis (Mayer-Rokitansky-Küster-Hauser Syndrome, MRKH)Psychosomatics, 2009
- Anxiety and depression in adolescents with polycystic ovary syndrome and Mayer-Rokitansky-Küster-Hauser syndromeJournal of Psychosomatic Obstetrics & Gynecology, 2009