Phthalate exposure and lung disease: the epidemiological evidences, plausible mechanism and advocacy of interventions
- 26 September 2022
- journal article
- research article
- Published by Walter de Gruyter GmbH in Reviews on Environmental Health
- Vol. 39 (1), 37-45
- https://doi.org/10.1515/reveh-2022-0077
Abstract
Phthalates are a kind of synthetic plasticizers, which extensively used as plastic productions to improve their plasticity and flexibility. However, exposure to phthalates has been proved an increased risk of respiratory disease, because by they affect the development and functions of the lung and immune system. Here, we attempt to review respiratory health of phthalate exposure. Firstly, we describe the relationship between phthalates and lung function and airway inflammation. Then, the role of phthalates in asthma, lung cancer, rhinitis, and respiratory tract infections and the possible mechanisms of action are discussed. Finally, possible effective measures to reduce exposure to phthalates are proposed, and health care workers are called upon to provide educational resources and advocate for informed public health policies. Overall, the evidence for association between phthalate exposure and respiratory disease is weak and inconsistent. Therefore, thorough implementation in large populations is needed to produce more consistent and robust results and to enhance the overall understanding of the potential respiratory health risks of phthalate in long-term exposure.Keywords
Funding Information
- Anhui Province University Outstanding Youth Talent Support Program (gxyq2019014)
- Anhui Medical University Clinical Pharmacology and Pharmacology Co-construction Project (2020)
- National Natural Science Foundation of China (82073566)
This publication has 67 references indexed in Scilit:
- Children’s Urinary Phthalate Metabolites and Fractional Exhaled Nitric Oxide in an Urban CohortAmerican Journal of Respiratory and Critical Care Medicine, 2012
- Mono-2-ethylhexylphthalate (MEHP) induces TNF-α release and macrophage differentiation through different signalling pathways in RAW264.7 cellsToxicology Letters, 2011
- Predicted risk of childhood allergy, asthma, and reported symptoms using measured phthalate exposure in dust and urineIndoor Air, 2011
- Acute Respiratory Inflammation in Children and Black Carbon in Ambient Air before and during the 2008 Beijing OlympicsEnvironmental Health Perspectives, 2011
- An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical ApplicationsAmerican Journal of Respiratory and Critical Care Medicine, 2011
- Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn ratsjpme, 2010
- Mono(2-ethylhexyl) phthalate induces both pro- and anti-inflammatory responses in rat alveolar macrophages through crosstalk between p38, the lipoxygenase pathway and PPARαInhalation Toxicology, 2009
- Tumorigenesis in B6C3F1 mice exposed to ozone in combination with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and dietary dibutyl phthalateToxicology and Industrial Health, 2009
- Mortality from lung cancer in an acetylene and phthalic anhydride plant. A case-referent study.Scandinavian Journal of Work, Environment & Health, 1983
- Polyvinyl Chloride Pyrolysis ProductsArchives of environmental health, 1975