Vitamin D Receptor (VDR) Gene Polymorphisms and Risk of Coronary Artery Disease (CAD): Systematic Review and Meta-analysis
- 15 February 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Biochemical Genetics
- Vol. 59 (4), 813-836
- https://doi.org/10.1007/s10528-021-10038-x
Abstract
Several studies have noted that vitamin D receptor (VDR) gene polymorphisms are involved in the susceptibility to Coronary artery disease (CAD). Nonetheless, the results have been inconclusive. Here, we performed the most up-to-date analysis of the association between VDR gene polymorphisms and risk of CAD. We conducted a comprehensive systematic search in the major electronic database, including Scopus and PubMed to look up for relevant studies evaluating the association between the VDR gene FokI (rs2228570), TaqI (rs731236), BsmI (rs1544410), and ApaI (rs7975232) polymorphisms and susceptibility to CAD published before December 2019. The level of association between VDR gene polymorphisms and susceptibility to CAD in the polled analysis was calculated by odds ratio (OR) and the corresponding 95% confidence interval (CI). We found 14 articles containing 20,398 cases and 9371 controls. The analysis revealed that all genetic models in the FokI SNP were associated with increased risk of CAD. Furthermore, for the ApaI SNP, except recessive model, all other genetic models significantly increased the risk of CAD in the overall analysis. In addition, it was divulged that both FokI and ApaI SNPs were involved in increasing the risk of CAD in Asians and Europeans in a number of models. FokI and ApaI polymorphisms may confer a susceptibility genetic risk factor for development of CAD, particularly in the Asian population.Keywords
This publication has 51 references indexed in Scilit:
- Allelic variations of the vitamin D receptor (VDR) gene are associated with increased risk of coronary artery disease in type 2 diabetics: The DIABHYCAR prospective studyDiabetes & Metabolism, 2013
- Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analysesEuropean Journal of Epidemiology, 2010
- Cardiovascular Disease Risk Factors: Epidemiology and Risk AssessmentThe American Journal of Cardiology, 2010
- No Association Between Vitamin D Receptor Polymorphisms and Coronary Artery Disease in a Chinese PopulationDNA and Cell Biology, 2009
- Burden of Coronary Artery Disease in Adults With Congenital Heart Disease and Its Relation to Congenital and Traditional Heart Risk FactorsThe American Journal of Cardiology, 2009
- Vitamin D Receptor Activators Can Protect against Vascular CalcificationJournal of the American Society of Nephrology, 2008
- Association of Vitamin D Receptor Gene Polymorphism and Parkinson's Disease in KoreansJournal of Korean Medical Science, 2005
- Coronary artery disease in the developing worldAmerican Heart Journal, 2004
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986