Second heart sound splitting as an indicator of interventricular mechanical dyssynchrony using a novel splitting detection algorithm
Open Access
- 5 January 2021
- journal article
- research article
- Published by Wiley in Physiological Reports
- Vol. 9 (1), e14687
- https://doi.org/10.14814/phy2.14687
Abstract
Second heart sound (S2) splitting results from nonsimultaneous closures between aortic (A2) and pulmonic valves (P2) and may be used to detect timing differences (dyssynchrony) in relaxation between right (RV) and left ventricle (LV). However, overlap of A2 and P2 and the change in heart sound morphologies have complicated detection of the S2 splitting interval. This study introduces a novel S‐transform amplitude ridge tracking (START) algorithm for estimating S2 splitting interval and investigates the relationship between S2 splitting and interventricular relaxation dyssynchrony (IRD). First, the START algorithm was validated in a simulated model of heart sound. It showed small errors (p < .001), accompanied by a decrease in mean IRD from 8 ms to −18 ms (p < .001). S2 splitting interval was significantly correlated with IRD in each experiment (p < .001). In conclusion, the START algorithm can accurately assess S2 splitting and may serve as a useful tool to assess interventricular dyssynchrony.This publication has 29 references indexed in Scilit:
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