Synthesis of deuterated γ-linolenic acid and application for biological studies: metabolic tuning and Raman imaging
- 29 January 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 57 (17), 2180-2183
- https://doi.org/10.1039/d0cc07824g
Abstract
γ-Linolenic acid (GLA) is reported to show tumor-selective cytotoxicity via unidentified mechanisms. We introduced deuterium into GLA as a dual functional tag for metabolic inhibition and Raman imaging and applied for mechanistic studies.Keywords
Funding Information
- Japan Society for the Promotion of Science (JP18K14360, JP20K15418)
- RIKEN
- Japan Agency for Medical Research and Development (JP18gm071004)
- Ministry of Education, Culture, Sports, Science and Technology (JP26110004)
- Core Research for Evolutional Science and Technology (JPMJCR1925)
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