A treatment algorithm to identify therapeutic approaches for leg ulcers in patients with sickle cell disease
- 4 November 2015
- journal article
- review article
- Published by Wiley in International Wound Journal
- Vol. 13 (6), 1315-1324
- https://doi.org/10.1111/iwj.12522
Abstract
Sickle cell leg ulcers (SCLUs) are a common complication of sickle cell disease (SCD). Patients who develop ulcers appear to have a more severe haemolysis‐associated vasculopathy than individuals who do not develop them, and manifest other complications such as priapism and pulmonary hypertension. SCLUs are slow to heal and often recur, affecting both the emotional and physical well‐being of patients. Here we summarise what is known about the pathophysiology of SCLUs, describe available treatment options and propose a treatment algorithm.This publication has 66 references indexed in Scilit:
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