Energy efficiency in buildings, comprises many things as mitigation effect of global warming and climate change, decreasing heat island effect in the built environment and also conservation of natural resources. Besides as a new phenomenon we should add biophilic design criteria to the green building tools to increase human productivity by considering human wellbeing. Biophilic design, which inspired by nature, is a new juvenile design concept that gains importance day by day because of its positive effects on human wellbeing mood and relatedly human productivity. Here some conflicts can be occurred between energy saving and human wellbeing; as natural ventilation and energy saving. Biophilic design comprises inherent human inclination to affiliate with nature. All sensations which help to be in contact with natural components as daylight, plants or some animal species like birds; plants occupy an important place in its definition. Biophilic design seeks to create good habitat for people as a biological organism in the modern built environment that promotes people’s health, fitness and wellbeing. Scientific studies reveal that contact with nature has significant effects on people’s physical and mental health, performance and wellbeing. This phenomenon has, an increasing importance more than ever before, especially in daily life. The need for beneficial contact with nature continues in today’s built environment. This paper aims to determine whether the biophilic design strategies are match with green building tools that mostly targeting energy saving in built environment. Also paper handling whether the 14 biophilic design patterns are match with 3 main mind-body systems that are; stress reduction, cognitive performance and emotion mood preference.