Water-Promoted Reaction of C60Ar5Cl Compounds with Thiophenes Delivers a Family of Multifunctional Fullerene Derivatives with Selective Antiviral Properties

Abstract

Here we report a reaction of the fullerene derivatives C₆₀Ar₅Cl, which enables the substitution of Cl with thiophene residues and the formation of the novel family of C₁-symmetrical C₆₀ fullerene derivatives with six functional addends C₆₀Ar₅Th. The discovered reaction provided a straightforward approach to the synthesis of previously inaccessible multifunctional water-soluble fullerene derivatives, including the compounds with antiviral activity against human immunodeficiency and influenza viruses.