Methylphenidate decreases the EEG mu power in the right primary motor cortex in healthy adults during motor imagery and execution
- 17 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Brain Structure and Function
- Vol. 226 (4), 1185-1193
- https://doi.org/10.1007/s00429-021-02233-8
Abstract
This study investigated the effects of dopaminergic drugs on the EEG mu power during motor imagery, action observation, and execution. This is a double-blind, crossover study with a sample of 15 healthy adults under placebo vs. methylphenidate vs. risperidone conditions during motor imagery, action observation, and execution tasks. The participants had drug dosage adjustment based on body weight/dose (mg/kg). We also analyzed the mu band power by electroencephalography during the study steps. The main result is the interaction between the condition and task factors for the C3 and C4 electrodes, with decreasing EEG mu power in the methylphenidate when compared to risperidone (p ≤ 0.0083). Our results can indicate that the methylphenidate decreases the neurophysiological activity in the central cortical regions during the perceptual experience of tasks with or without body movement.Keywords
This publication has 52 references indexed in Scilit:
- EEG feature comparison and classification of simple and compound limb motor imageryJournal of NeuroEngineering and Rehabilitation, 2013
- Cortical dynamics of human scalp EEG origins in a visually guided motor executionNeuroImage, 2012
- Neural Activation and Functional Connectivity during Motor Imagery of Bimanual Everyday ActionsPLOS ONE, 2012
- Methylphenidate produces selective enhancement of declarative memory consolidation in healthy volunteersPsychopharmacology, 2011
- Role of the Primary Motor Cortex in the Early Boost in Performance Following Mental Imagery TrainingPLOS ONE, 2011
- Strength gains by motor imagery with different ratios of physical to mental practiceFrontiers in Psychology, 2011
- Effects of Methylphenidate on performance of a practical pistol shooting task: a quantitative electroencephalography (qEEG) studyInternational Archives of Medicine, 2011
- Effects of methylphenidate on motor system excitability in a response inhibition taskBehavioral and Brain Functions, 2009
- Cognition-Enhancing Doses of Methylphenidate Preferentially Increase Prefrontal Cortex Neuronal ResponsivenessBiological Psychiatry, 2008
- Motor imagery and action observation: cognitive tools for rehabilitationJournal of Neural Transmission, 2007