Development of hepatic pathology in GBV‐B‐infected red‐bellied tamarins (Saguinus labiatus)
Open Access
- 17 March 2020
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 92 (12), 3584-3595
- https://doi.org/10.1002/jmv.25769
Abstract
GB virus B (GBV‐B) is a New World monkey‐associated flavivirus used to model acute hepatitis C virus (HCV) infection. Critical for evaluation of anti‐viral or vaccine approaches is an understanding of the effect of HCV on the liver at different stages of infection. In the absence of longitudinal human tissue samples at defined time points, we have characterised changes in tamarins. As early as two weeks post infection histological changes were noticeable, and these were established in all animals by six weeks. Despite high levels of liver‐associated viral RNA there was reversal of hepatic damage on clearance of peripheral virus though fibrosis was demonstrated in four tamarins. Notably, viral RNA burden in the liver dropped to near undetectable or background levels in all animals which underwent a second viral challenge, highlighting the efficacy of the immune response in removing foci of replication in the liver. These data add to the knowledge of GBV‐B infection in New World primates which can offer attractive systems for the testing of prophylactic and therapeutic treatments and the evaluation of their utility in preventing or reversing liver pathology.This publication has 29 references indexed in Scilit:
- Hepatic immunopathology during occult hepacivirus re-infectionVirology, 2017
- Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus InfectionJournal of Virology, 2016
- Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infectionsFrontiers in Microbiology, 2014
- Changes in immune cell populations in the periphery and liver of GBV-B-infected and convalescent tamarins (Saguinus labiatus)Virus Research, 2013
- Virus-Specific T-Cell Immunity Correlates with Control of GB Virus B Infection in MarmosetsJournal of Virology, 2008
- Immunity against the GBV‐B hepatitis virus in tamarins can prevent productive infection following rechallenge and is long‐livedJournal of Medical Virology, 2007
- GB virus B infection of the common marmoset (Callithrix jacchus) and associated liver pathologyJournal of General Virology, 2004
- Development of a GB Virus B Marmoset Model and Its Validation with a Novel Series of Hepatitis C Virus NS3 Protease InhibitorsJournal of Virology, 2004
- Host range studies of GB virus‐B hepatitis agent, the closest relative of hepatitis C virus, in New World monkeys and chimpanzees†Journal of Medical Virology, 2001
- Studies of GB hepatitis agent in tamarinsJournal of Hepatology, 1989