Diagnosis of Chlamydia trachomatis genital infections in the era of genomic medicine
Open Access
- 23 June 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Brazilian Journal of Microbiology
- Vol. 52 (3), 1327-1339
- https://doi.org/10.1007/s42770-021-00533-z
Abstract
Purpose: Chlamydial genital infections constitute significant sexually transmitted infections worldwide. The often asymptomatic status ofC. trachomatis(CT) infections leads to an increased burden on human reproductive health, especially in middle- and low-income settings. Early detection and management of these infections could play a decisive role in controlling this public health burden. The objective of this review is to provide an insight into the evolution of diagnostic methods for CT infections through the development of new molecular technologies, emphasizing on -omics’ technologies and their significance as diagnostic tools both for effective patient management and control of disease transmission.Methods: Narrative review of the diagnostic methodologies of CT infections and the impact of the introduction of -omics’ technologies on their diagnosis by review of the literature.Results: Various methodologies are discussed with respect to working principles, required specifications, advantages, and disadvantages. Implementing the most accurate methods in diagnosis is highlighted as the cornerstone in managing CT infections.Conclusion: Diagnostics based on -omics’ technologies are considered to be the most pertinent modalities in CT testing when compared to other available methods. There is a need to modify these effective and accurate diagnostic tools in order to render them more available and feasible in all settings, especially aiming on turning them to rapid point-of-care tests for effective patient management and disease control.Keywords
Funding Information
- Manipal Academy of Higher Education, Manipal
This publication has 119 references indexed in Scilit:
- Whole-genome sequences of Chlamydia trachomatis directly from clinical samples without cultureGenome Research, 2013
- Whole-genome analysis of diverse Chlamydia trachomatis strains identifies phylogenetic relationships masked by current clinical typingNature Genetics, 2012
- High-Resolution Genotyping of Chlamydia trachomatis by Use of a Novel Multilocus Typing DNA MicroarrayJournal of Clinical Microbiology, 2011
- Evaluation of a Novel Chlamydia trachomatis Microsphere Suspension Assay for Detection and Genotyping of the Different Serovars in Clinical SamplesThe Journal of Molecular Diagnostics, 2011
- Clinic-Based Evaluation of a Rapid Point-of-Care Test for Detection of Chlamydia trachomatis in Specimens from Sex Workers in Escuintla, GuatemalaJournal of Clinical Microbiology, 2009
- Genital Chlamydia trachomatis infectionsClinical Microbiology & Infection, 2009
- Genotyping of Chlamydia trachomatis by Microsphere Suspension ArrayJournal of Clinical Microbiology, 2008
- Prevalence of Chlamydia trachomatis Infection among Low- and High-Risk Filipino Women and Performance of Chlamydia Rapid Tests in Resource-Limited SettingsJournal of Clinical Microbiology, 2007
- Distribution Study ofChlamydia trachomatisSerovars among High-Risk Women in China Performed Using PCR-Restriction Fragment Length Polymorphism GenotypingJournal of Clinical Microbiology, 2007
- Clinic-based evaluation of Clearview Chlamydia MF for detection of Chlamydia trachomatis in vaginal and cervical specimens from women at high risk in ChinaSexually Transmitted Infections, 2006