Coupled liquid biopsy and bioinformatics for pancreatic cancer early detection and precision prognostication
Open Access
- 15 February 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Molecular Cancer
- Vol. 20 (1), 1-12
- https://doi.org/10.1186/s12943-021-01309-7
Abstract
Early detection and diagnosis are the key to successful clinical management of pancreatic cancer and improve the patient outcome. However, due to the absence of early symptoms and the aggressiveness of pancreatic cancer, its 5-year survival rate remains below 5 %. Compared to tissue samples, liquid biopsies are of particular interest in clinical settings with respect to minimal invasiveness, repeated sampling, complete representation of the entire or multi-site tumor bulks. The potential of liquid biopsies in pancreatic cancer has been demonstrated by many studies which prove that liquid biopsies are able to detect early emergency of pancreatic cancer cells, residual disease, and recurrence. More interestingly, they show potential to delineate the heterogeneity, spatial and temporal, of pancreatic cancer. However, the performance of liquid biopsies for the diagnosis varies largely across different studies depending of the technique employed and also the type and stage of the tumor. One approach to improve the detect performance of liquid biopsies is to intensively inspect circulome and to define integrated biomarkers which simultaneously profile circulating tumor cells and DNA, extracellular vesicles, and circulating DNA, or cell free DNA and proteins. Moreover, the diagnostic validity and accuracy of liquid biopsies still need to be comprehensively demonstrated and validated.Funding Information
- Natural Science Foundation of China (82072632)
This publication has 99 references indexed in Scilit:
- Microvesicle-mediated Transfer of MicroRNA-150 from Monocytes to Endothelial Cells Promotes AngiogenesisOnline Journal of Public Health Informatics, 2013
- Classification, Functions, and Clinical Relevance of Extracellular VesiclesPharmacological Reviews, 2012
- A pilot study to explore circulating tumour cells in pancreatic cancer as a novel biomarkerBritish Journal of Cancer, 2011
- ROLE OF ENDOSCOPIC ULTRASOUND‐GUIDED FINE NEEDLE ASPIRATION (EUS‐FNA) FOR DIAGNOSIS OF SOLID PANCREATIC MASSESDigestive Endoscopy, 2011
- Perioperative cancer cell dissemination detected with a real-time RT-PCR assay for EpCAM is not associated with worse prognosis in pancreatic ductal adenocarcinomaBMC Cancer, 2011
- Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAsPLOS ONE, 2010
- Metastasis: from dissemination to organ-specific colonizationNature Reviews Cancer, 2009
- Detection of tumor cell dissemination in pancreatic ductal carcinoma patients by CK 20 RT-PCR indicates poor survivalZeitschrift für Krebsforschung und Klinische Onkologie, 2005
- Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant DiseasesClinical Cancer Research, 2004
- Carcinoembryonic Antigen Messenger RNA Expression Using Nested Reverse Transcription-PCR in the Peripheral Blood During Follow-up Period of Patients Who Underwent Curative Surgery for Biliary-Pancreatic CancerClinical Cancer Research, 2004